The first autoresponders were created within mail transfer agents that found they could not deliver an e-mail to a given address. These create bounce messages such as "your e-mail could not be delivered because..." type responses. Today's autoresponders need to be careful to not generate e-mail backscatter, which can result in the autoresponses being considered E-mail spam.
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would it be possible to add a feature where you can connect the auto-responder to a filter? E.g. if the filter detects a msg from my mother in law, it will always respond i am on vacation or otherwise unreachable. but if msg comes it from my collegues, i could respond with a different msg (like if you really really need to reach me call this number)